Mosca is an Italian surname. Notable people with the surname include:
Alessia Mosca (born 1975), Italian politician
Angelo Mosca (1937–2021), Canadian Football League player and professional wrestler
Antonio Mosca (1870–1951), Italian painter
Bianca Mosca (dead 1950), London-based fashion designer
Claudio Mosca (born 1991), Argentine footballer
Enrique Mosca (1880-1950), Argentine lawyer and politician
Frank Mosca (born 1976), American film producer
Gaetano Mosca (1858–1941), Italian political scientist, journalist, and public servant
Giuseppe Mosca (1772–1839), Italian opera composer
Jacopo Mosca (born 1993), Italian cyclist
John Mosca (restaurateur) (1922–2011), American restauranteur, founder of Mosca's
John Mosca (musician) (born 1950), American jazz trombonist
Lino Mosca (1907−1992), Italian professional football player
Luigi Mosca (1775–1824), Italian composer of operas and sacred music, and singing teacher
Maurizio Mosca (1940–2010), Italian sports journalist and television presenter
Michele Mosca, Italian physics researcher and professor of mathematics
Paolo Mosca (1943–2014), Italian journalist, writer, singer, and television presenter
Pierre Mosca (born 1949), Italian-born French former footballer and coach
Rafael Mosca (born 1982), Brazilian swimmer
Rich Mosca (born c. 1948), former American football player and coach
Sal Mosca (1927–2007), American jazz pianist
Simone Mosca (1492–1554), Italian sculptor
Stefania Mosca (1957–2009), Venezuelan writer
Tommaso Mosca (born 2000), Italian racing driver
Fictional characters
Mosca, of Ben Jonson's 1606 play Volpone
Mosca, of The Godfather Part III
Frank Mosca, of Miami Vice
Gola Mosca, of Reborn! manga and anime series
Walter Mosca, of Mario Puzo's novel The Dark Arena