Recurring
John Hostetter as John, the stage manager at FYI.
Ritch Brinkley as Carl Wishnitski, a cameraman at FYI who has an ongoing attraction to Murphy.
Alan Oppenheimer as Gene Kinsella, a news-division executive. Seen as a recurring character in seasons 1–5, Kinsella is generally supportive of and liked by his FYI staff. In-show, the character is let go from his position and replaced with...
Julius Carry as Mitchell Baldwin, the Machiavellian new boss who replaces Gene Kinsella. Baldwin, a Black man used the team's liberal-Caucasian guilt to railroad through changes in FYI's format and content. Appears in seasons 5 and 6, and in a dream sequence in season 8. Essentially superseded as the network thorn in FYI's side by...
Garry Marshall as Stan Lansing, the very excitable, aggressive, and micro-managing network president. His frequent and impromptu whims are the bane of the FYI staff. Seen fairly regularly in seasons 6–9, and one final time in season 10.
Paul Reubens as Andrew J. Lansing III, Stan Lansing's sociopathic nephew. He is introduced as one of Murphy's 93 secretaries du jour and was one of only three who measure up to Murphy's standards. Like the few other secretaries who were actually competent, Andrew is lured away from Murphy by another job by the end of the episode; in his case, he is promoted to a network executive position through nepotism. He periodically appears in later episodes, although his network career is wildly unpredictable, largely due to the mercurial nature of his uncle and mentor—at various times, Andrew is a network VP, an executive producer, and a mailboy. Seen as an occasional character in seasons 7–9.
Christopher Rich as Miller Redfield, an empty-headed, pretty-boy reporter with a local affiliate who had semi-regular appearances on the show. At first, he was a recurring substitute anchor, but after a gap of a few years, he became a regular member of the FYI team —- although the rest of the team frequently (usually unsuccessfully) conspired to get rid of him. Later co-hosted a separate news show with Murphy called Front and Center, produced out of the same office. Seen once per season in seasons 2–4, he was then seen very frequently in seasons 7–9.
Wallace Shawn as Stuart Best, a buffoonish former FYI reporter who annoyed Murphy, Jim, and Frank to the point that the three colluded to have him fired —- twice. After the second firing, Stuart returned as a hopelessly inept party-line politician who invariably broke down under even the most sympathetic questions by Murphy while on-air. Appeared once a season in seasons 6–9.
Scott Bakula as Peter Hunt, a reporter and occasional love interest of Murphy's. Seen in seasons 6 through 8.
Paula Cale as McGovern, a conservative young reporter based on MTV's Kennedy. She was added to the program when management tried to appeal to a younger demographic. Seen for a run of episodes as a regular towards the end of season 7, the character was then quietly dropped without explanation and never mentioned again.
Colleen Dewhurst as Avery Brown, a museum curator and Murphy's opinionated mother. Dewhurst won two Emmy Awards for her appearances, appearing in a total of four episodes in seasons 1–3. When Dewhurst died in 1991, the writers chose to have her character die as well, and dedicated the episode to the memory of Dewhurst. Murphy, who was pregnant at the time of her mother's death, named her son Avery in her mother's memory the following season.
Darren McGavin as Bill Brown, a newspaper publisher and Murphy's father. Bill shared an adversarial relationship with his ex-wife Avery—especially after marrying Karen, a fresh-faced twenty-something who taught yoga. McGavin appeared in four episodes as Bill Brown (in seasons 2, 4 and 5) and earned an Emmy nomination in 1990 for his performance.
Jay Thomas as Jerry Gold, an abrasive tabloid talk show host who became a friend of Murphy's and an occasional love interest, despite their significantly different journalistic values. Seen in seasons 2–4; returns in a dream sequence in 8, and in one episode (now about to get married) during season 10.
Robin Thomas as Jake Lowenstein, an underground leftist radical and Murphy's ex-husband from long before her FYI days. Seen very infrequently, for a total of five episodes in seasons 1, 3, 4 and 8. Murphy and Jake had a brief relationship during season three, which resulted in Murphy's pregnancy.
Jane Leeves as Audrey Cohen, Miles' girlfriend, seen occasionally in seasons 2–5. Though she and Miles were headed for marriage, the relationship ended abruptly—offscreen, Leeves joined the cast of Frasier in 1993, and was no longer available to appear on Murphy Brown.
Janet Carroll (seasons 2–9) and Concetta Tomei (season 10) as Doris Dial, anchorman Jim Dial's equally stoic, but kind-hearted wife.
Pat Finn as Phil Jr. (ten episodes in Seasons 8 and 9), Phil's son who, though somewhat empty-headed, takes on running Phil's Bar after his father dies.
Dena Dietrich as Phyllis (two episodes in Season 2 & one episode in Season 9), Phil's wife and mother of their four children: Little Phil, Phillip, Felicia, & Phil Jr.
Andre Ward as Julius, the stage manager of Murphy in the Morning.
Merle Dandridge as Diana Macomber, the head of cable news network CNC, which airs Murphy in the Morning.