Nogales is a Spanish surname. Notable people with the surname include:
Armando López Nogales (born 1950), Mexican former lawyer and politician
Daniel Nogales (born 2003), Spanish racing driver
Diego Nogales (born 1981), Spanish football manager
Esteban Muñoz Nogales (born 1984), Spanish former professional footballer
Eva Nogales, Spanish biophysicist
Francisco Nogales (born 1946), Spanish pathologist
Jose Luis Morales Nogales (born 1987), Spanish professional footballer
José Nogales (1860–1908), Spanish journalist and writer
José Nogales Sevilla (1860–1939), Spanish painter and watercolorist
Manuel Chaves Nogales (1897–1944), Spanish journalist and writer
Mariana Nogales Molinelli (born 1973), Puerto Rican lawyer, politician, and social activist
Paola Nogales-Ascarrunz (born 1994), Bolivian biologist
Rafael de Nogales, Venezuelan adventurer