Novo is a Portuguese and Galician surname. Notable people with the surname include:
Álvaro Novo (born 1978), Spanish footballer
Emanuel Novo (born 1992), Portuguese footballer
Ferruccio Novo (1897–1974), Italian footballer
Honório Novo (born 1950), Portuguese politician
Ignacio Novo Sampol, Cuban exile and militant
Luís Novo (born 1970), Portuguese long-distance runner
Nacho Novo (born 1979), Spanish footballer
Nancho Novo (born 1958), Spanish actor
Pelayo Novo (born 1990), Spanish footballer
Salvador Novo (1904–1974), Mexican writer and poet