Ōtsuka (大塚 or 大束; lit. "large mound" or "large bundle" (respectively)) is a Japanese surname. Alternative transliterations include Otsuka and Ohtsuka. Notable people with the surname include:
Ai Otsuka (大塚 愛, born 1982), Japanese pop singer from the Kansai region
Akinori Otsuka (大塚 晶則, born 1972), Japanese baseball player
Akio Ōtsuka (大塚 明夫, born 1959), Japanese voice actor, son of Chikao Ohtsuka
Alexander Otsuka (Real name Takashi Otsuka) (大塚 崇, born 1971), Japanese professional wrestler and mixed martial artist
Chihiro Otsuka (大塚 ちひろ, born 1986), Japanese actress
Chikao Ohtsuka (大塚 周夫, 1929–2015), Japanese voice actor, father of Akio Ōtsuka
Gen Ōtsuka (大束 元, 1912–1992), Japanese photographer
Hirofumi Otsuka (大塚 博文, born 1947), Japanese speed skater
Hironori Ōtsuka (大塚 博紀, 1892–1982), creator and first Grand Master of the Japanese karate style Wado-ryu
Hōchū Ōtsuka (大塚 芳忠, born 1954), Japanese voice actor
James Otsuka (1921–1984), war tax resister
Julie Otsuka (born 1962), Japanese American author
Ken Otsuka (大塚 健; born 1970), Japanese animator storyboarded Japanese anime My Hero Academia
Kohei Otsuka (大塚 耕平, 1959–2026), Japanese politician
Michael Otsuka (born 1964), American political philosopher
Miyako Ōtsuka (大塚 宮子, born 1953), Japanese basketball player
Miyu Otsuka (大塚 美優, born 1994), Japanese swimmer
Motoyuki "Morrie" Ōtsuka (大塚 基之, born 1964), Japanese singer-songwriter
Noyuri Otsuka (1924–2019), Japanese Christian scholar and researcher
Tadashi Ohtsuka (大束 忠司, born 1978), Japanese badminton player
Tarō Ōtsuka (大塚 太郎, 1868–?), Japanese garden designer: see T. R. Otsuka
T. R. Otsuka (1868–?), Japanese garden designer
Tatsunori Otsuka (大塚 達宣; born 2000), Japanese volleyball player
Takeo Otsuka (大塚 武生, born 1966), Japanese professional wrestler also known as Men's Teioh or Terry Boy
Takeru Otsuka (大塚 健; born 2001), Japanese snowboarder
Yasuo Ōtsuka (大塚 康生, born 1931), animator
Yuto Otsuka (大塚 裕土, born 1987), Japanese basketball player
Sae Ōtsuka (大塚 紗英, born 1995), Japanese voice actor, singer