Assistant Director at Universal
Karlson got a job at Universal Pictures, doing a variety of jobs.
He worked as assistant director on Destry Rides Again (1932) and My Pal, the King with Tom Mix; The Countess of Monte Cristo (1934) and Cheating Cheaters (1934) with Fay Wray; I Like It That Way (1934); Romance in the Rain (1934); and Strange Wives (1934), directed by Richard Thorpe.
He worked on The Mystery of Edwin Drood (1935) with Claude Rains; Princess O'Hara (1935); Alias Mary Dow (1935), for Kurt Neumann; Werewolf of London (1935); Sing Me a Love Song (1935); She Gets Her Man (1935); The Affair of Susan (1935); Love Before Breakfast (1936), with director Walter Lang; The Girl on the Front Page (1936); and Top of the Town (1937).
Karlson said that Sam Goldwyn put him under contract intending to use him as a director, but Karlson wound up spending nine months idle. He asked for a release of his contract and got it. He joined a company of Maurice Kosloff.
He went back to Universal where he worked as an assistant on The Black Doll (1938); The Case of the Missing Blonde (1938); The Last Express (1938); His Exciting Night (1938), The Last Warning (1938), Newsboys' Home (1938), and Society Smugglers (1939), directed by Joe May.
His credits became more distinguished: Rio (1939), with Basil Rathbone, directed by John Brahm; The Invisible Man Returns (1940) and The House of the Seven Gables for May; I Can't Give You Anything But Love, Baby (1940), a musical; You're Not So Tough (1940), for May; Margie (1940), Seven Sinners (1940), with John Wayne and Marlene Dietrich for director Tay Garnett; Where Did You Get That Girl? (1941), for Arthur Lubin; and The Flame of New Orleans (1941), with Dietrich for René Clair.
Karlson did In the Navy (1941) with Abbott and Costello for Lubin, and he became friendly with Lou Costello, often pitching him gags. He worked on It Started with Eve (1941) for Henry Koster with the studio's other big star, Deanna Durbin.
Karlson quit Universal in 1940 to enlist in the U.S. Army Air Forces. In 1943, he was injured in a plane crash ending his career as a flight instructor.