Family
With Elisabeth of France (1602–1644, daughter of Henry IV of France) — married 18 October 1615 at Bordeaux:
Maria Margaret of Austria, Infanta of Spain (14 August 1621 – 15 August 1621), died at a day old and was buried at El Escorial
Margaret Maria Catherine of Austria, Infanta of Spain (25 November 1623 – 22 December 1623), died at a month old and was buried at El Escorial
Maria Eugenia of Austria, Infanta of Spain (21 November 1625 – 21 August 1627), died at 1 and was buried at El Escorial.
Isabella Maria Theresa of Austria, Infanta of Spain (31 October 1627 – 1 November 1627 also died at a day old and buried at El Escorial as her three older sisters Maria Eugenia, Margaret Maria Catherine and Maria Margaret were.)
Balthasar Charles of Austria, Infante of Spain, Prince of Asturias (17 October 1629 – 9 October 1646), Prince of Asturias.
Maria Anna "Mariana" Antonia of Austria, Infanta of Spain (17 January 1636 – 5 December 1636 died at 12 months old and was buried at El Escorial with her four older sisters, last child of Philip IV of Spain to die in early childhood or infancy by his first wife Isabella of Bourbon.)
Maria Theresa of Austria, Infanta of Spain (1638–1683), married Louis XIV of France and had issue.
With Archduchess Maria Anna of Austria (1634–1696) – his niece – married 1649:
Margaret Theresa of Austria, Infanta of Spain (12 July 1651 – 12 March 1673), married Leopold I, Holy Roman Emperor
Maria Ambrosia de la Concepción Enrichetta Theresa of Austria, Infanta of Spain (7 December 1655 – 21 December 1655)
Philip Prospero of Austria, Infante of Spain, Prince of Asturias (28 November 1657 – 1 November 1661)
Ferdinand Thomas Charles of Austria, Infante of Spain (23 December 1658 – 22 October 1659)
Charles II of Spain (6 November 1661 – 1 November 1700) married Marie Louise d'Orléans, no issue. Married secondly Maria Anna of Neuburg, no issue.
King Philip IV had many extramarital affairs, and an unknown but large number of illegitimate children, estimated around thirty. Only two were legitimized.
With María Manrique, daughter of the marqués de Charela
Fernando Francisco Isidro de Austria (15 May 1626 – 12 March 1634), legitimized after his death and buried at El Escorial
With María Calderón:
John Joseph of Austria (7 April 1629 – 17 September 1679), legitimized in 1642.
Never legitimized:
Carlos Fernando de Austria y Manrique (1639-1696), married, one daughter.
Alonso Antonio de San Martín (1636-1705), Bishop of Oviedo and of Cuenca.
Ana Margarita de Austria (1641-1699), Prioress of the Royal Monastery of La Encarnación.
Alfonso Enríquez de Santo Tomás (1631-1692), Bishop of Málaga.
Fernando Valdés (1638-1702), married, Governor of Novara in Italy.
Juan Cossío (1640-1701), Augustinian monk.