Principe is a surname of Spanish and Italian origin. Notable persons with that surname include:
Gene Principe (born 1967), Canadian sports reporter
Joe Principe (born 1974), American rock guitarist
Lawrence M. Principe, American historian of science
Maria Matilde Principi (1915–2017), Italian entomologist
Nick Principe (born 1978), American actor
John Principe (born 1997) social media editor at The Score