Film career
Rosemary and Priscilla remained with Fred Waring for almost five years. In 1937, Waring was engaged by Warner Bros. in Hollywood to appear with his entire band in Varsity Show, a musical starring Dick Powell. Both Rosemary and Priscilla were tested and awarded feature roles in the film. Rosemary shared the romantic passages with Powell, while Priscilla played a high-spirited college girl.
Warner Bros. purchased Priscilla and Rosemary's contract from Fred Waring and signed them to seven-year pacts. Priscilla's first film after Varsity Show was Men Are Such Fools (1938), in which she starred with Wayne Morris. This was followed by Love Honor and Behave (also 1938), another light romantic comedy with Morris, who, playing her husband, spanked her 47 times in a scene for which she declined a double, and Cowboy from Brooklyn, again teaming with Dick Powell. The publicity department at the studio suggested that Priscilla and Morris be seen together around town. They liked each other and did date for a period; however, Priscilla later said it was never serious on either side.
Also in 1938, Priscilla, Rosemary and third sister Lola Lane appeared as three of four sisters (the fourth being Gale Page) in Four Daughters, the similarly themed Daughters Courageous the following year, and two sequels to Four Daughters a few years later, Four Wives and Four Mothers.
Priscilla was next assigned the lead in Brother Rat, which had been a very successful Broadway play. Again she played opposite Wayne Morris, and among the cast were newcomers Ronald Reagan, Jane Wyman, Jane Bryan, and Eddie Albert. The film, when released in October 1938, was a big success for all the young players. At this time of professional success, the sisters were informed that Mullican had died in Iowa.
After winning her raise, Priscilla returned to work, but the films assigned to her were no better than those she had turned down. Brother Rat and a Baby (aka, Baby Be Good, 1940) was an inferior sequel and Three Cheers for the Irish (also 1940) gave her little to do.
The British Picturegoer magazine, always a supporter of the Lane Sisters, stated that all was not right with Priscilla Lane. In its June 15, 1940 issue, they wondered why "Priscilla was still knocking at the door of major stardom". They felt Warner Bros. was casting her as stooge to such actors as John Garfield and James Cagney. They went on to say Priscilla had great charm and while not a really great dramatic actress, deserved much larger and more important roles than she was getting. The same magazine, two years later on August 22, 1942, referred to their 1940 article and once again expressed disappointment at Warners' treatment of the star. They were unaware that she had already left the studio.
On April 28, 1941, she was heard on Lux Radio Theater with George Brent and Gail Patrick in Wife, Husband and Friend. At Warner Bros. she appeared in a lighthearted comedy, Million Dollar Baby (1941), opposite Ronald Reagan, and as a night club singer in Blues in the Night (also 1941).
Frank Capra requested her for the lead opposite Cary Grant in Arsenic and Old Lace. The comedy film was completed in early 1942, but was not released until 1944; it was held up by contractual agreement not to distribute the film until the play's long Broadway run was over. It was Priscilla's last Warner film. Her contract was terminated by mutual agreement after five years with the studio.
She freelanced next, signing a one-picture deal with Universal Studios where she starred with Robert Cummings in Alfred Hitchcock's Saboteur (1942). The director did not want either Cummings or Lane for their roles. Hitchcock felt Lane was too much the girl next door. Universal insisted that they play the leads, and when the film was released, her acting was praised while some criticism was focused on Hitchcock for reworking so much from his earlier films into this wartime spy drama.
She had commitments for two more films. The first was Silver Queen (1942) for producer Harry Sherman in which she co-starred with George Brent. She played the owner of a gambling house in 1870s San Francisco. The other film was a Jack Benny comedy, The Meanest Man in the World, released in January 1943. Lane then retired from films. For the duration of the war, she followed her husband across America as he moved from one military base to another. She was generous with her talents and often performed at camp shows.
While living in Van Nuys, she was offered and accepted the leading role in Fun on a Weekend (1947) for producer–director Andrew Stone, co-starring Eddie Bracken. When the film was released, Variety opined, "Miss Lane, who's been absent from films for some time, gives a good enough performance which should ensure her work in more pictures." However, Lane returned to domestic life. Once again she and her husband moved, this time to Studio City.
Lane accepted the offer of the lead role opposite Lawrence Tierney in a film noir, Bodyguard (1948), starring as Doris Brewster. During an interview with a Hollywood correspondent, she stated, "I didn't realize how much I miss filming until I came back. I love this work, and I hope to make many, many more pictures." Bodyguard would be her last picture. An expected contract with RKO Studios did not come to pass.
In January 1951, Cora Mullican died at the San Fernando Valley home her daughters had bought for her years earlier. Priscilla returned to show business briefly in 1958 with her own show on a local television station broadcasting from Boston. Titled The Priscilla Lane Show, she chatted and interviewed celebrities visiting the area. She enjoyed the television experience, but family demands proved too much, and she gave up after a year.