Sole reign
In AD 23 or 24, Juba II died and was buried alongside his wife in the Royal Mausoleum. Ptolemy became the sole ruler of Mauretania and also inherited his father's honorary position as duumvir quinquennalis of Carthago Nova. The title of duumvir quinquennalis was given to the two chief magistrates of a town or colony, who served a five-year term together. During the Julio-Claudian era, members of the imperial family were often given honorary titles as magistrates of prominent cities in the Roman Empire. Other dignitaries with personal ties to the emperor sometimes also received honorary appointments as duumvir.
Around the time of Ptolemy's ascension, Publius Cornelius Dolabella, the Roman proconsul of Africa, was sent to stop Tacfarinas' rebellion. Ptolemy assisted Dolabella’s successful campaign against Tacfarinas, which saw the rebel leader killed at Augea. The Roman Senate honoured Ptolemy for his conduct in the war, naming him a 'friend and ally of the Roman people'. The Senate sent him further honours in AD 24, including a ceremonial ivory sceptre, gold crown, curule seat, and toga picta. The toga picta was a purple toga with gold decorations, traditionally worn by victorious generals during a Roman triumph. Tiberius permitted client kings to wear the toga picta, which his predecessor Augustus had not allowed. Mauretanian coins minted by Ptolemy portray the gifts that he received from the Senate. Historian Duane W. Roller considered the war to be an important episode in Ptolemy's career that demonstrated his competence, while Anthony A. Barrett suggested that he did not contribute much to the campaign's success and the Romans only honoured him as a diplomatic gesture because of his popularity.
During the reign of Ptolemy, Mauretania was an important producer of grain, olive oil, garum, rare Tyrian purple dye, and luxury woods like citrus, olive, and cedar. It exported these goods to Rome, as well as exotic animals that were used for spectacles in the Colosseum. This trade made Mauretania prosperous, and Ptolemy's wealth reportedly aroused the jealousy of his cousin emperor Caligula. Unlike his father, who had a reputation for being a scholarly king, Ptolemy was reputed to be an immature ruler who was controlled by members of his court. Near the end of his reign, Ptolemy began to act independently of Rome. He also minted an issue of Mauretanian gold coins, which he might not have been permitted to do as a client king.
Little is known of the king's personal life. A woman named 'Queen Urania' is mentioned on an inscription from Caesarea, and might have been associated with the Mauretanian royal court during Ptolemy's reign. She has been identified as his concubine or wife. Egyptologist Chris Bennett suggested that Urania might have been married to Juba II at the end of his life, but considered it more likely that she was Ptolemy's wife.