Radcliffe is a surname. Notable people with the name include:
Alex Radcliffe (1905–1983), American baseball player
Ann Radcliffe (1764–1823), English novelist
Aubrey Radcliffe (1933–2009), American academic
Bill Radcliffe (1917–1984), Manx teacher and Manx-Gaelic language advocate
Charles Radcliffe (1941–2021), English magazine editor
Cyril Radcliffe, 1st Viscount Radcliffe (1899–1977), British lawyer
Daniel Radcliffe (born 1989), English actor
Egremont Radcliffe (died 1578), English rebel
Eric Radcliffe (born 1950), British recording engineer and music producer
George Radcliffe (politician) (1593–1657), English politician
George L. P. Radcliffe (1877–1974), American politician from Maryland
John Radcliffe, disambiguation
Mark Radcliffe, disambiguation
Mary Radcliffe, disambiguation
Melva Radcliffe (1901–2012), American centenarian from New Jersey
Mike Radcliffe (born 1944), Canadian politician
Paula Radcliffe (born 1973), English athlete
Percy Radcliffe (1916–1991), Manx politician
Richard Radcliffe (died 1660), English politician
Rosemary Radcliffe (born 1949), Canadian actress
Seán Radcliffe (born 2005), Irish Activist
Ted Radcliffe (1902–2005), American baseball player
Timothy Radcliffe (born 1945), Master of the Order of Preachers (Dominicans)