Ragusa is a surname. Notable people with the surname include:
Antonino Ragusa, (born 1990) Italian footballer
Carmine Ragusa, fictional character from "Laverne & Shirley"
Cinzia Ragusa (born 1977), Italian water polo player
Eleonora Ragusa (1861–1939), also known as Kiyohara Tama, Kiyohara Otama, or Ragusa Tama, Japanese painter
Kym Ragusa (born 1966), American writer and film director
Vincenzo Ragusa (1841–1927), Italian sculptor hired by the Japanese government