Early career
He entered the film world in the mid-1980s working under the tutelage of Jay and Lewis Allen. He worked on TV shows such as Divorce Court, The Osbournes, and America's Next Top Model.
Glatzer used his experience working in day time television to create his first independent film, Grief (1993), a comedy-drama focusing on a writer for a trashy daytime TV show who comes to grips with office politics, a co-worker crush and homophobia. It premiered at San Francisco's Frameline Festival, where it won the Audience Award for Best Picture. It starred Craig Chester, Illeana Douglas, Alexis Arquette, Jackie Beat, Carlton Wilborn, and Lucy Gutteridge.
Glatzer taught screenwriting at the School of Visual Arts in New York City.
Glatzer and Wash Westmoreland were a married writing and directing team based in Los Angeles who made an eclectic set of independent movies. Their last film, Still Alice, with Julianne Moore, Alec Baldwin, and Kristen Stewart, premiered at Toronto 2014 and was considered the surprise hit of the festival. The movie was picked up by Sony Pictures Classics, who released the film in December 2014. Glatzer died of ALS, and some critics have suggested a connection between his own experience with illness and the raw, honest depiction of illness in the film.