Manchester United
On 22 July 2002, Ferdinand joined fellow Premier League side Manchester United on a five-year deal to become the most expensive British footballer in history at the time and the world's most expensive defender for a second time, a title he had lost in 2001 to Lilian Thuram. Ferdinand went on to win the Premier League title with Manchester United in his first season at the club. He collected a winner's medal in the 2006 League Cup, with runners-up medals in the 2003 League Cup and the 2005 FA Cup.
In September 2003, he failed to attend a drug test scheduled to take place at United's Carrington training ground. Ferdinand had left after training to go shopping, only to remember and attempt to return, only to be told it was too late. He later undertook the test and passed, and also later offered to have a hair follicle test, but the FA turned down the offer. The Football Association (FA) Disciplinary Committee, chaired by Barry Bright, imposed an eight-month ban from January 2004 at club and international level and a £50,000 fine, meaning he would miss the rest of the season and some of the next along with all of Euro 2004. United appealed against the verdict and sought to draw parallels to the case of Manchester City player Christian Negouai, who was fined £2,000 for missing a test. In the end, the original verdict was upheld. In September, it was announced that he would make his return against Liverpool; Alex Ferguson praised his "assuredness and composure" as United won the match 2–1.
In a fixture against Charlton Athletic in May 2005, United supporters booed Ferdinand amidst his refusal to sign a new contract. Ferdinand still hadn't signed a new contract in July and faced pressure from Ferguson to sign it, taking away his position as vice-captain. Ferdinand was booed during several pre-season friendlies in July and August, before finally signing a new four-year contract. Ferdinand later reflected on the saga, saying how he used it as motivation to change the views of United's supporters from negative to positive.
On 14 December, in a game against Wigan Athletic, Ferdinand scored his first goal for United, en route to a 4–0 victory. He followed this later in the month with a powerfully headed goal against West Bromwich Albion. On 22 January 2006, Ferdinand scored a last minute winner against Liverpool at Old Trafford. In the corresponding fixture in the following season on 22 October, Ferdinand scored again in a 2–0 victory.
Following impressive and consistent performances in the league, Rio Ferdinand was named in the 2006–07 PFA Premiership Team of the Season, alongside seven of his Manchester United teammates.
Ferdinand started the 2007–08 season well, he was part of a United defence that managed to keep six clean sheets in a row in the Premier League, before conceding an early goal to Aston Villa at Villa Park on 20 October 2007. It was also during this game where Ferdinand scored his first goal of the season, which was United's third goal of that game, with a left foot strike which took a very strong deflection off one of Villa's defenders. Just three days later, Ferdinand scored his first European goal for United by opening the scoring against Dynamo Kyiv, with a superb header. United dominated the game and won 4–2.
On 12 January 2008, Ferdinand bagged a rare Premier League goal in a 6–0 hammering of Newcastle United at Old Trafford. In their FA Cup quarter-final match against Portsmouth on 8 March 2008 when Manchester United dominated, Ferdinand made a rare appearance as a goalkeeper, after Edwin van der Sar left the pitch with a groin injury and the replacement keeper, Tomasz Kuszczak, was sent off after conceding a penalty. Despite diving the right way, he was unable to save Sulley Muntari's spot kick, and Manchester United were eliminated from the FA Cup. On 6 April 2008, against Middlesbrough, Ferdinand limped out of the match due to a foot injury. He was rated doubtful whether he would face A.S. Roma in the UEFA Champions League quarter-final second leg on 9 April 2008. He would play the full 90 minutes, though he received three stitches at half-time.
After United's 2–1 loss to Chelsea in the Premier League in April 2008, Ferdinand swore at Chelsea stewards and tried to kick a wall in the tunnel, but instead kicked a female steward, Tracy Wray. Ferdinand claimed to have merely brushed her with his foot. He said he had apologised and sent the steward some flowers. However, Wray showed the bruise on her leg to the media, and her husband claimed that Ferdinand had not apologised or sent flowers.
It was announced on 18 April 2008 that, along with Michael Carrick and Wes Brown, Ferdinand had agreed to sign a new five-year contract, worth around £130,000 a week, that would keep him with United until 2013. On 21 May 2008, Ferdinand captained Manchester United to a Champions League Final victory versus Chelsea. He accepted the trophy together with Ryan Giggs, as Giggs was the on field captain for most of the matches during that season during Gary Neville's absence due to injury.
In an interview with BBC Radio 5 Live he criticised FIFA's approach to tackling racism in football, stating that not enough was being done to punish those guilty of homophobic or racist abuse at matches. Regarding taunts aimed at Emile Heskey in England's 4–1 victory against Croatia in Zagreb, Ferdinand remarked:"Croatia were fined a few thousand quid. What's that going to do? That is not going to stop people shouting racist or homophobic abuse...If things like this keep happening you have to take points off them. Then the punters will realise the team is going to be punished."
Ferdinand had an injury plagued 2009–10 season, a number of back and knee injuries kept him on the sidelines for months. He returned to action on 28 January 2010, but was banned for four games after being found guilty of violent conduct for elbowing Hull City's Craig Fagan.
Due to a knee injury he suffered in the summer of 2010, which ruled him out of the World Cup for England, he missed all of pre-season, the Community Shield and the first four games of the 2010–11 Premier League season. He returned to first-team football in the opening game of the Champions League group stage against Rangers on 14 September. He captained the side and played the full 90 minutes in a goalless draw. He started the season opening game in August 2011, the 2011 FA Community Shield, where United found themselves 2–0 down at half time to city rivals Manchester City. Ferdinand was taken off after 45 minutes along with defensive partner Nemanja Vidić and replaced by Jonny Evans and Phil Jones respectively. United went on to win the game 3–2 and Ferdinand claimed his fourth Community Shield medal of his career. Ferdinand started in the opening Premier League match of the season at West Bromwich Albion, a game United won 2–1, but he went off with a hamstring injury after 75 minutes. After the match, Alex Ferguson confirmed that Ferdinand would be out for six weeks. Ferdinand however recovered much quicker than initially diagnosed and returned to take a place on the bench two weeks later at Old Trafford in United's 8–2 demolition of Arsenal, although he did not play a part in the game. Ferdinand made his return to competitive action in a 1–1 draw against Stoke City at the Britannia Stadium.
On 9 December 2012, Ferdinand was struck and injured by a coin thrown from the home crowd during United's 3–2 derby victory away from home against Manchester City.
On 5 March 2013, Ferdinand, unhappy with the referee Cüneyt Çakır's decision to send off Nani during a 2–1 Champions League defeat to Real Madrid at Old Trafford, clapped sarcastically in the referee's face after the game. He escaped any punishment from UEFA for the incident.
On 12 May 2013, Ferdinand scored the winner and final goal of the Alex Ferguson era at Old Trafford in a 2–1 victory over Swansea City. After a corner was missed by everyone, the ball found its way to Ferdinand at the back post and he hit it on the volley to seal the win. On 23 May 2013, it was announced that Ferdinand had secured a new one-year contract that would see him stay with the club until the end of the 2013–14 season. He was not offered an extension when that contract expired, and agreed to leave Manchester United on 12 May 2014. In a letter on his official website, he said "I am feeling fit and healthy, ready for a new challenge and looking forward to whatever the future holds for me."