Bibliography (selected)
Singh S, Weindorfer C, Nandi A, Selvam CP, Götze MM, Das M, Fallacshino A, Tjendra Y, Boone M, Dolznig H, Zhang Q, Clarke R, Thomas C & Chakrabarti R. (2025) DLL1-responsive PD-L1+ tumor-associated macrophages promote endocrine resistance in breast cancer. Science Translational Medicine, 17: eadr6207. PMID: 41191774
Farsani SSM, Soni J, Jin L, Yadav AK, Bansal S, Mi T, Hilakivi-Clarke LA, Clarke R, Youngblood B, Cheema A. & Verma V. (2025) Pyruvate kinase M2 reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy. Cell Metabolism, S1550-4131(25)00106-8. PMID: 40199327
Korangath P, Jin L, Yang C-T, Healy S, Guo X, Ke S, Hu C, Gabrielson K, Foote J, Clarke, R. & Ivkov, R. (2024) Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer. ACS Nano 18:10509-10526. PMID: 38564478
O'Sullivan CC, Clarke R, Goetz MP & Robertson JF. (2023) Cyclin Dependent 4/6 Kinase inhibitors for treatment of hormone receptor positive, HER2-negative breast cancer: past successes, current challenges, and future directions. JAMA Oncology, 9: 1273-1282. PMID: 37382948
Fan M, Xia P, Clarke R, Wang Y & Li L. (2020) Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer. Nature Communications, 11:4861. PMID: 32978398
Cook KL, Soto-Pantoja DR, Clarke PAG, Cruz I, Zwart A, Wärri A, Roberts DD, & Clarke, R. (2016) Endoplasmic reticulum stress protein, GRP78, modulates lipid metabolism to control breast tumor drug sensitivity and activate anti-tumor immunity. Cancer Research, 76:5657-5670. PMID: 27698188
Schwartz-Roberts JL, Cook KL, Chen C, Shajahan-Haq AN, Axelrod M, Wärri A, Riggins RB, Jin L, Haddad BR, Kallakury BV, Baumann WT & Clarke, R. (2015) Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate. Cancer Research, 75: 1046-1055. PMID: 25576084
Hu R, Wärri A, Jin L, Zwart A, Riggins RB & Clarke R. (2015) NFκB signaling is required for XBP1 (U and S) mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer cells. Molecular and Cellular Biology, 35: 379-390. PMID: 25368386
Chen C, Baumann WT, Xing J, Xu L, Clarke R. & Tyson JJ. (2014) Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer. Journal of the Royal Society Interface, 11: 20140206. PMID: 24806707
Cook KL, Shajahan AN, Jin L, Wärri A, Hilakivi-Clarke LA & Clarke R. (2012) Glucose regulated protein 78 controls crosstalk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Research, 72: 3337-3349. PMID: 22752300
Tyson JJ, Baumann WT, Chen C, Verdugo A, Tavassoly I, Wang Y, Weiner LM & Clarke R. (2011) Dynamic modelling of estrogen signaling and cell fate in breast cancer cells. Nature Reviews Cancer, 11: 523–532. PMID: 21677677
Clarke R, Ressom H W, Wang A, Xuan J, Liu MC, Gehan EA & Wang Y. (2008) The properties of high-dimensional data spaces: implications for exploring gene and protein expression data. Nature Reviews Cancer, 8: 37–49. PMID: 18097463
Wang LH, Yang XY, Zhang X, An P, Kim H-J, Huang J, Clarke R, Osborne CK, Inman JK, Appella E & Farrar WL. (2006) Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell, 10: 487-499. PMID: 17157789
Trock B J, Hilakivi-Clarke L, & Clarke R. (2006). Meta-analysis of soy intake and breast cancer risk. Journal of the National Cancer Institute, 98: 459–471. PMID: 16595782
Bouker KB, Skaar TC, Fernandez DR, O’Brien KA, Riggins RB, Honghua C & Clarke, R. (2004) Interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (Faslodex, Fulvestrant). Cancer Research, 64: 4030-4039. PMID: 15173018
Pratt MAC, Bishop TE, White D, Yasvinski G, Ménard M, Niu MY & Clarke R. (2003) Estrogen withdrawal-induced NF-κB and Bcl-3 expression in breast cancer cells: roles in growth and hormone independence. Molecular and Cellular Biology, 23: 6887-6900. PMID: 12972607
Arteaga CL, Koli KM, Dugger TC & Clarke R. (1999) Reversal of tamoxifen resistance of human breast carcinomas in vivo with neutralizing anti-transforming growth factor (TGF)-β antibodies. Journal of the National Cancer Institute, 91: 46-53. PMID: 9890169
Trock BJ, Leonessa F & Clarke R. (1997) Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance. Journal of the National Cancer Institute, 89: 917–931. PMID: 1359153
Clarke R, Brünner N, Katzenellenbogen BS, Thompson EW, Norman MJ, Koppi C, Paik S, Lippman ME & Dickson RB (1989). Progression from hormone dependent to hormone independent growth in MCF-7 human breast cancer cells. Proceedings of the National Academy of Sciences USA, 86: 3649–3653. PMID: 2726742
