Rodrigo de Castro Osorio was a Spanish cardinal and churchman. He was Bishop of Zamora (1574–1578) and the Diocese of Cuenca (1578–1581), Archbishop of Seville, (1581–1600), a member of the Council of State of Spain and the Supreme Council of the Spanish Inquisition during the reign of Philip II of Spain. He was the Great-uncle of Pedro Fernández de Castro y Andrade, Conde de Lemos. He was closely linked to the city of Monforte de Lemos in Galicia, where he was the founder of the College of Our Lady of Antigua.
- Occupation
- Catholic priest
- Position held
- cardinal, Roman Catholic Bishop of Cuenca, Roman Catholic Bishop of Zamora, Roman Catholic Archbishop of Seville
- Citizenship
- Spain
