Ruxandra Lăpușneanu (1538 – 21 November 1570) was a princess consort of Moldavia by her marriage to Alexandru Lăpușneanu in 1564. Ruxandra was the daughter of Peter IV Rareș and Princess Elena Ecaterina Rareș (the second daughter of Jovan Branković of Serbia). From 1568 until 1570 she was regent in Moldavia on behalf of her son Bogdan IV of Moldavia.