Career expansion (2015–present)
Shortly after leaving EastEnders, Strike was cast in a starring role in the crime drama film Bonded by Blood 2, which was released in 2017. He guest-starred as David Hamilton in a two-part episode of the television series Silent Witness and as Clyde Barrow in an episode of the television series Timeless, both in 2016. In the 2017 prequel to the film The Texas Chain Saw Massacre titled Leatherface, directed by Julien Maury and Alexandre Bustillo, he played the lead role of Jackson / Leatherface. Reviewing the film for Variety, Dennis Harvey described the cast's performances as "solid", adding that "the younger actors throw themselves into the task with aplomb." On television, Strike portrayed real-life serial killer Montie Rissell in an episode of Mindhunter, also in 2017.
In 2018, Strike had main roles in the horror thriller film Monster Party, and in the Syfy series Nightflyers. Frank Scheck of The Hollywood Reporter called the former "gleefully gory and darkly funny", and singled out Strike and Virginia Gardner's performances writing that they "prove adept with the challenging physical demands placed on them." The following year, Strike appeared as Misha in the episode "1:23:45" of the HBO miniseries Chernobyl, and was cast in the lead role of Roland Deschain in the Amazon Studios adaptation of Stephen King's book series The Dark Tower. The latter was ultimately cancelled, producing only an unaired pilot.
Strike starred as Casper Tatum in the 2020 Quibi coming-of-age murder mystery series When the Streetlights Go On. The critics praised the show's "strong writing, an impressive cast, and most importantly, an intriguing mystery". Strike also appeared in a 2020 episode of the television series FBI: Most Wanted playing Ronnie Lee Bishop, and in a 2022 episode of the Netflix series The Sandman as Todd. He portrayed Ryan Dougherty in the 2023 true crime drama American Outlaws, which earned him and his co-stars an award for Best Ensemble Cast at the Boston Film Festival. In George Clooney's 2023 film adaptation of Daniel James Brown's book The Boys in the Boat, he played American rower Roger Morris. The film received mixed reviews from critics. In 2024, Strike had a recurring role of Deputy Jess Chinlund in season two of the Amazon Studios series Outer Range. In 2026, he was cast in the Apple TV series Star City as Soviet cosmonaut Pavel Fetisov. He is next set to star in Frankie Shaw's upcoming dark comedy film 4 Kids Walk Into a Bank, an adaptation of Matthew Rosenberg and Tyler Boss' graphic novel of the same name.