Social issues
According to the Sydney Morning Herald, Henderson is a member of the National Right faction of the Liberal Party, after previously being aligned with the Centre-Right faction during the Morrison government years.
She was a supporter of same-sex marriage in Australia. In a statement, released in June 2015, she stated that marriage equality "is consistent with fundamental Liberal values which embrace freedom of the individual and stable, long-term relationships". She also advocated for a free vote on the floor of parliament on the issue for Coalition MPs.
By 2017, under the Prime Ministership of Malcolm Turnbull leading up to a discussion on the marriage equality plebiscite within the Liberal Party room, Henderson shifted in favour of the plebiscite, stating that the plebiscite concept had "resonated very positively in the community".
Henderson is pro-choice on the issue of abortion, which has drawn ire from more conservative elements within the Victorian Liberal Party. Nonetheless, on the floor of Parliament, on the question on whether the federal government should ensure that all Australians have access to abortion services, Henderson has almost always voted along party lines.
Henderson is opposed to voluntary euthanasia. In October 2017, she tweeted an article written by former Prime Minister Paul Keating arguing against such legislation, adding that Victoria's euthanasia bill would "embed a culture of dying" in the state.
Henderson supported state Liberal MP Moira Deeming when the state Liberal Party Leader proposed expelling her for her part in organising a women’s rights rally which was attended by neo-Nazis.