Social issues
Moulton supports abortion rights and same-sex marriage. He supports legal immigration and advocates for immigration reform, but opposes illegal immigration and has called it "something we have to confront".
In August 2023, Moulton was one of nine House Democrats who voted in favor of a Republican-led amendment to the National Defense Authorization Act (NDAA) prohibiting the teaching of "race-based theories" in schools operated by the Department of Defense Education Activity, introduced by Rep. Chip Roy. It was opposed by most Democrats as part of a broader Republican effort to target so-called "Critical Race Theory".
Moulton endorsed a 2016 Massachusetts ballot measure, Question 3, designed to protect the welfare of farmed animals. The measure prohibited Massachusetts farmers from "knowingly cause any covered animal to be confined in a cruel manner" and prohibited the sale of eggs or meat from animals that did not meet the standards.
In 2022, Moulton was among a bipartisan group of 19 members of Congress who called on the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS) to enact federal protections for cephalopods (such as octopuses, squid, and cuttlefish) used in laboratory research and to update federal animal welfare policies to include these species, and he helped lead congressional letters to NIH and HHS reiterating these requests.
Moulton has acknowledged having used cannabis and supports its legalization, saying, "If you're not buying your marijuana from a dealer who sells heroin, who sells opioids, it's much less likely to be a gateway drug. The problem is now that it operates in the shadows. There's no control whatsoever. Someone goes and buys an edible, for example, there's no regulation about what's in that. It's like moonshine under Prohibition."
In 2022, Moulton wrote the legislation which shortened the phone number for the National Suicide and Mental Health Crisis Hotline to 988. He also introduced the Brandon Act, a law intended to improve mental health access for active duty armed service members.
In 2022 and 2023, Moulton cosponsored the Transgender Bill of Rights and voted in favor of the Equality Act.
Following Kamala Harris's loss to Donald Trump in the 2024 presidential election, Moulton expressed opposition to transgender participation in girls' sports. Moulton commented: "'I have two little girls, I don't want them getting run over on a playing field by a male or formerly male athlete, but as a Democrat I'm supposed to be afraid to say that'". Following his remarks, his campaign manager, Matt Chilliak, resigned in protest, and his comments were condemned by Salem mayor Dominick Pangallo and by Massachusetts state Rep. Manny Cruz, the vice-chair of the Salem School Committee. He also faced protest from constituents. Moulton released a response on November 8, 2024 defending his statement.
Moulton said in a follow-up interview that it was "kind of weird" to include pronouns after signatures in emails. He later asserted that Trump's policies would be "extremely harmful" to transgender children and that transgender children "deserve our support", but still described Democrats as "out of touch" on transgender issues. On November 13, 2024 the Salem Democratic City Committee vowed to find someone to run against Moulton in the Democratic primaries for the 2026 midterm elections due to his comments, with the chair of the local Democratic committee in Salem referring to him in an email as a "cooperator" in "Nazi times." On November 17, hundreds of people in Salem gathered at his office in the town at a rally held in protest at his remarks, co-organized by city councillor Kyle Davis.
On November 25, 2024 Moulton said in an interview with the Rolling Stone that the media, in particular The New York Times, had misrepresented his position on transgender issues following the election. Moulton clarified that he still supports transgender rights, but simply wanted Democrats to be more open to talking about the issue. Moulton additionally said that he was not proposing that Democrats should ban transgender women from women's sports, but instead just "wanted [Democrats] to have a message to fight back against attacks". He also described Nancy Mace's attacks on transgender rights following the election as "abhorrent".
In January 2025 Moulton voted against the "Protection of Women and Girls in Sports Act" which would have banned trans women and girls from competing in women's sports nationwide, commenting that the bill was "too extreme". Moulton condemned Donald Trump's Executive Order 14168, but said the Democratic Party should "stop denying that this is an issue" and "have a response". In September 2025, Moulton co-sponsored the 988 LGBTQ+ Youth Access Act of 2025, a House bill seeking to restore funding to the 988 Suicide and Crisis Lifeline, specifically for LGBTQ+ services.
In November 2025, after announcing his bid for the US Senate, Moulton said he supported trans rights and vowed to "support and lead legislation like the Transgender Bill of Rights" if he is elected to the Senate. Moulton also said that there "is no room in the Democratic Party for complete opposition to trans rights" and he vowed to "fight to pass full federal LGBTQ+ anti-discrimination policies" and support the Equality Act. Moulton mentioned that he had listened to feedback from people who "were hurt by how [he] framed [his] comments in the past about the best way to protect the trans community". Moulton reiterated that his "intent has always been to push our party to have honest, tough conversations so we can fight back more effectively against the far-right attacks on LGBTQ Americans. I remain committed to protecting the rights and dignity of transgender Americans".
In August 2026, when his Democratic primary opponent Ed Markey, attacked Moulton for abandoning trans children with his earlier remarks, Moulton accused Markey of being "just like the Republicans" for "injecting a divisive social issue into the primary campaign". Moulton also said that despite his previous apology, he was "not sorry for the substance of his earlier remarks".