Reign
Seti II promoted Chancellor Bay to become his most important state official and built 3 tombs – KV13, KV14, and KV15 – for himself, his Senior Queen Tausert and Bay in the Valley of the Kings. This was an unprecedented act on his part for Bay, who was of Syrian descent and was not connected by marriage or blood ties to the royal family. Because Seti II had his accession between II Peret 29 and III Peret 6 while Siptah—Seti II's successor—had his accession around late IV Akhet to early I Peret 2, Seti's 6th and final regnal year lasted about 10 months; therefore, Seti II ruled Egypt for 5 years and 10 months or almost 6 full years when he died.
Due to the relative brevity of his reign, Seti's tomb was unfinished at the time of his death. Tausert later rose to power herself after the death of Siptah, Seti II's successor. According to an inscribed ostraca document from the Deir el-Medina worker's community, Seti II's death was announced to the workmen by "The [Chief of] police Nakht-min" on Year 6, I Peret 19 of Seti II's reign. Since it would have taken time for the news of Seti II's death to reach Thebes from the capital city of Pi-Ramesses in Lower Egypt, the date of I Peret 19 only marks the day the news of the king's death reached Deir el-Medina. Seti II likely died sometime late in IV Akhet or early in I Peret; Wolfgang Helck and R.J. Demarée have now proposed I Peret 2 as the date of Seti II's actual death, presumably since it is 70 days before the day of his burial. From a graffito written in the first corridor of Twosret's KV14 tomb, Seti II was buried in his KV15 tomb on "Year 1, III Peret day 11" of Siptah's reign.
Seti II's earliest prenomen in his First Year was 'Userkheperure Setepenre' which is written above an inscription of Messuy, a Viceroy of Nubia under Merneptah, on a rock outcropping at Bigeh Island. However, Messuy's burial in Tomb S90 in Nubia has been discovered to contain only funerary objects naming Merneptah which suggests that 1) Messuy may have died during Merneptah's reign and 2) Seti II may have merely associated himself with an official who had actively served his father as Viceroy of Kush. Seti II soon changed his royal name to 'Userkheperure Meryamun', which was the most common form of his prenomen.
Two important papyri date from the reign of Seti II. The first of these is the "Tale of Two Brothers", a fabulous story of troubles within a family on the death of their father, which may have been intended in part as political satire on the situation of the two half brothers. The second is the records of the trial of Paneb. Neferhotep, one of the two chief workmen of the Deir el-Medina necropolis, had been replaced by Paneb, his troublesome son-in-law. Many crimes were alleged by Neferhotep's brother—Amennakhte—against Paneb in a violently worded indictment preserved in papyrus now in the British Museum. If Amennakhte's testimony can be trusted, Paneb had allegedly stolen stone from the tomb of Seti II while still working on its completion—for the embellishment of his own tomb—besides purloining or damaging other property belonging to that monarch. Paneb was also accused of trying to kill Neferhotep, his adopted father-in-law, despite being educated by the latter and after the murder of Neferhotep by 'the enemy,' Paneb had reportedly bribed the Vizier Pra'emhab in order to usurp his father's office. Whatever the truth of these accusations, it is clear that Thebes was going through very troubled times. There are references elsewhere to a 'war' that had occurred during these years, but it is obscure to what this word alludes—perhaps to no more than internal disturbances and discontent. Neferhotep had complained of Paneb's attacks on himself to the vizier Amenmose, presumably a predecessor of Pra'emhab, whereupon Amenmose had punished Paneb. This trouble-maker had then brought a complaint before 'Mose' (i.e., 'Msy'), who then acted to remove Pra'emhab from his office. Evidently this 'Mose' must have been a person of the highest importance, perhaps the king Amenmesse himself or a senior ally of the king.
At Deir el-Medina, an usurped fragment of a wall relief show two cartouches being replaced with that of Seti II.
Seti II also expanded the copper mining at Timna Valley in Edom, building an important temple to Hathor, the cow goddess, in the region. It was abandoned in the late Bronze Age collapse, where a part of the temple seems to have been used by Midianite nomads, linked to the worship of a bronze serpent discovered in the area. Seti II also founded a station for a barge on the courtyard in front of the pylon II at Karnak, and chapels of the Theban Triad – Amun, Mut and Khonsu.