2000s
In 2003, she lent her voice to an episode of the Disney cartoon Kim Possible as Vivian Porter. Also in 2003, she was cast in James Wan's low budget horror film, Saw, as Amanda Young. A small part, opposite Tobin Bell, she filmed her scene within one day and while battling the flu. While initially a direct-to-video release was planned, test screenings in March 2004 turned out positive prompting Lionsgate to release it theatrically that October. It became a box office success, grossing $103 million worldwide. She would reprise her role in Saw II (2005), Saw III (2006), Saw VI (2009), and Saw X (2023). The Saw franchise went on to become one of the highest-grossing horror franchises of all time, grossing over $1 billion worldwide, as of 2021.
Smith began working on a solo album in 2004 with producer Chris Goss, but the project was never completed. In an interview with Radio Free in October 2005, she stated, "between being a mom, and working, and growing another baby, I have not had time to give attention to music for a while." Smith contributed to the soundtrack of Saw III in 2006 with vocals on Hydrovibe's song "Killer Inside", and to the soundtrack for Catacombs as a solo vocalist with the song "Please Myself".
In 2006, Smith made an appearance in the 10-minute short film trailer Repo! The Genetic Opera, directed by Bousman. The trailer was filmed after completing Saw III to try to pitch the idea to film producers. In 2007, she was part of a country rock music group with actress Missi Pyle called Smith & Pyle. Their first album, It's OK to Be Happy, was released digitally through iTunes and Amazon.com in 2008.
In 2008, Smith played Detective Gina Harcourt in the FEARnet original series 30 Days of Night: Dust to Dust and also served as executive producer. It premiered in July 17 with six webisodes. Smith was the host and one of three mentors on the VH1 reality television series, Scream Queens, which aired from October 2008 to December 2008. Smith did not return for the second season due to scheduling conflicts and was replaced with Jaime King.
Smith played the role of Dr. Sullivan, child psychiatrist, in The Grudge 3 that was released direct-to-video on May 12, 2009.
