Marriage and children
In or before 1608 Talbot married Alison, daughter of John Netterville of Castleton, County Meath.
William and Alison had eight sons:
Robert (1608 – aft. 1670), his successor
John
Garret (died before May 1671), married Margaret Gaydon and was father of William, the 3rd baronet
James
Thomas, a Franciscan, chaplain to Queen Henrietta Maria
Peter (1618 – 1680), became Catholic Archbishop of Dublin
Gilbert, a Confederate officer, married Dorothy Boyle, widow of Adam Loftus and sister of Roger Boyle, Earl of Orrery
Richard (1630–1691), became Earl of Tyrconnell and Lord Lieutenant of Ireland during the reign of James II, overhauling the Royal Irish Army that then fought in the Williamite War
—and eight daughters:
Mary, married Sir John Dongan, 2nd Baronet, and had at least ten children, including Sir Walter Dongan, 3rd Baronet, William Dongan, 1st Earl of Limerick, and Thomas Dongan, 2nd Earl of Limerick
Bridget
Margaret (died 1662), married Sir Henry Talbot of Templeogue
Frances, married James Cusack, son of Edward Cusack and grandson of Sir Thomas Cusack, Lord Chancellor of Ireland, and had three sons, Thomas, William and Nicholas
Elizabeth
Jane
Catherine
Eleanor, married Sir Henry O'Neill, 1st Baronet, of Killelagh, and was the mother of Sir Neil O'Neill and of Rose O'Neill, a foster daughter and heir-at-law of Rose MacDonnell, Marchioness of Antrim