2000 to 2010: Mainstream success
Kaneshiro’s work, however, is more heavily concentrated in China, Hong Kong, and Taiwan. In 2005, he sang his way through Perhaps Love, the first modern musical to be produced in China. It was the first of many collaborations with Hong Kong-based director Peter Chan. In 2008 and 2009 he starred in Red Cliff, a high budget film by Hong Kong director John Woo. He has also played the romantic lead in Zhang Yimou's House of Flying Daggers, and starred alongside Jet Li and Andy Lau in The Warlords. He expressed excitement when he received the news that he would have an opportunity to work with Director Zhang Yimou.
Kaneshiro has become well known in the video game industry portraying the samurai warrior Samanosuke in Capcom's Onimusha. In a June 2007 article on the film site Ain't It Cool News, it was revealed that Kaneshiro was going to be in the Onimusha film, reprising his role as Samanosuke and for a 2011 release, but that project was derailed. The producer Samuel Hadida had to delay the filming of Onimusha, which has resulted in the film's Japanese cast working on other film projects during the delay, and being unavailable to start filming. These factors were enough that French director Christophe Gans will now direct an adaptation of Leo Perutz's novel The Swedish Cavalier first, taking over the reins from Gilles Mimouni. Satomi Ishihara and Tsuyoshi Ihara remain attached to the project.
In 2003, Kaneshiro was featured in Time magazine and was dubbed the Johnny Depp of the East Asian film industry. Moreover, Kaneshiro was interviewed by journalist Hugh Riminton for CNN in the network’s TalkAsia segment in 2006.