Other work
In December 2011, Killam replicated the Robyn video "Call Your Girlfriend" in a small writer's room and posted it to YouTube. The video went viral and by February 2022, it had been viewed more than 1,277,875 times. The late night antics briefly became an Internet phenomenon and garnered Killam media and public attention. When interviewed on Late Night with Jimmy Fallon, Killam stated that he had not known the dance shown in the song's official video until Robyn was scheduled to appear on SNL as a guest; he watched the video repeatedly until he could perform it himself.
In 2011, Killam appeared in Community episode "Regional Holiday Music" as Mr. Radison (Mr. Rad), a parody of Will Schuester from Glee. In 2012, he appeared in iCarly episode "iMeet the First Lady" as a Secret Service agent.
Killam co-starred in the 2013 comedy film The Heat. Killam voices Zip "Frantic" Danger on the Hulu original series The Awesomes.
In 2013, Killam ventured into the spy genre and the comics industry with The Illegitimates, a six-issue comics miniseries co-written by Marc Andreyko, illustrated by Kevin Sharpe and published by IDW Publishing. The series focuses on a team of illegitimate siblings who are charged with taking the place of their father, Jack Steele, a James Bond-like spy, after his death. The first issue was published December 18, 2013, and received mixed reviews.
Killam appears in the 2013 film 12 Years a Slave, playing the role of Abram Hamilton, one of the men who abducts Solomon Northup into slavery.
Killam is a fan of the Teenage Mutant Ninja Turtles franchise, Raphael his favorite turtle, and successfully lobbied for a role in the 2014 film as Channel 5 staff.
Killam made six guest appearances as Gary Blauman on his wife Cobie Smulders' TV series, How I Met Your Mother. His first appearance was in the March 20, 2006, episode, "Life Among the Gorillas" and the final one was the March 24, 2014, episode, "The End of the Aisle".
From 2015 to 2025, Killam provided the voice of the titular character on the PBS Kids show Nature Cat, along with SNL alumni Kate McKinnon, Bobby Moynihan, and Kenan Thompson.
On January 17, 2017, Killam succeeded Rory O'Malley in the role of King George III in the Broadway musical Hamilton.
Killam produced, scripted, directed and starred in the comic hitman film Killing Gunther, given a general release in fall 2017. Arnold Schwarzenegger, who played Gunther in the film, served as executive producer for it.
In March 2018, Killam was cast as a lead in the comedy pilot Single Parents for ABC, which was picked up to series for a premiere on September 26 of that year.
Killam plays the recurring role of Ludo Radovic in the series High Potential, which started airing on ABC in 2024. He was slated to play the role of Officer Lockstock in New York City Center's Encores! 2025 production of Urinetown, but dropped out after losing his home in the January 2025 Southern California wildfires.
