Cast
Oscar Isaac as Mikael Boghosian, an Armenian medical student from the town of Siroun. Pietro A. Shakarian wrote in The Nation that Mikael "represents the aspirations of Ottoman Armenians" and that he "is almost like a hero in a work by one of the great Armenian national writers like Raffi or Khachatur Abovian".
Charlotte Le Bon as Ana Khesarian, an Armenian artist who was raised in Paris and studied at the Sorbonne. George stated that Ana represents a foreign-born "avant-garde, socially liberated woman" to Chris while she is drawn to Mikael as she rediscovers her Armenian roots. George experienced difficulty in casting Ana's role and indicated that he chose Le Bon after seeing her in a Canadian fashion magazine and meeting her in person as she would be able to play "a strong and independent character who could attract two very different types of men."
Christian Bale as Christopher Myers, a world-renowned American journalist with the Associated Press. Chris is a composite character of "a number of eyewitness reporters who witnessed sections of the genocide." Christian Bale joined the film production prior to the selection of George as the director. Bale studied Lincoln Steffens and other period journalists, such as Christopher Hitchens, as well as meeting with people who studied the genocide.
Marwan Kenzari as Emre Ogan, a notorious Turkish playboy and son of a diplomat. Ara Sarafian, director of the Gomidas Institute in London and a leading historian of the Armenian genocide, stated that it was "historically important" to have characters representing "righteous Muslims", including Emre. Shakarian states that Emre "represents the friendships that existed between Armenians and Muslims before the genocide and those Muslims who, later, went out of their way to save their Armenian friends and neighbors."
Shohreh Aghdashloo as Marta Boghosian, Mikael's mother.
Angela Sarafyan as Maral, Mikael’s betrothed in Siroun.
Daniel Giménez Cacho as Reverend Dikran Antreassian, a clergyman from Bassek who joins the resistance at Musa Dagh.
Tom Hollander as Garin, a former circus clown who is held prisoner in a labor camp.
Numan Acar as Mustafa, a Turk working for the American Red Cross driving orphans to safety.
Igal Naor as Mesrob Boghosian, Mikael’s wealthy uncle who owns a fabric store in Constantinople.
Milene Mayer Gutierrez as Yeva Boghosian, one of Mesrob and Lena’s two daughters.
Sofia Black-D'Elia plays an older Yeva in the film's epilogue.
Tamer Hassan as Faruk Pasha, an official in the Ottoman army.
Rade Šerbedžija as Stephan, the Mayor of Bassek, who leads the Armenian residents of Bassek to safety.
Alicia Borrachero as Lena Boghosian, Mesrob’s wife.
Abel Folk as Harut, Maral’s wealthy father.
Jean Reno as the French naval Admiral Louis Dartige du Fournet
James Cromwell as the American ambassador to the Ottoman Empire, Henry Morgenthau Sr.
Kevork Malikyan as Vartan Boghosian, Mikael’s father.
Stewart Scudamore as Ogan Pasha, Emre’s father, a Turkish diplomat.
Other actors in the film include Andrew Tarbet as Pastor Merrill, Aaron Neil as Talaat Pasha, Ozman Sirgood as Hasan Mazhar, Aharon Ipalé as Dr. Nazim, Lucía Zorrilla as Tamar, Roman Mitichyan as Van, Armin Amiri as Ali, Shnorhk Sargsyan as Komitas, Anthony Rotsa as Ahmet, Michael Stahl-David as Brad, Marco Khan as a Turkish nightwatchman, Simón Andreu as an Armenian peasant, and Vic Tablian as an Armenian prisoner.