Film and television
In 1986, Arnold appeared as Crystal, one of the three chorus girls who perform R&B numbers in Frank Oz's film musical Little Shop of Horrors (1986) along with future Martin co-star Tisha Campbell. Arnold was only sixteen at the time of filming, and her career continued steadily after that, with a role or two almost every year, including the films How I Got into College and the Paul Mazursky/Woody Allen collaboration Scenes from a Mall (1991). In February 1987 Arnold scored her first big break on television, with a permanent role on the soap opera Ryan's Hope. Her critically lauded role, as young heroine Zena Brown, landed her a Daytime Emmy Award nomination in 1988. She continued in the role until the series ended in January 1989. Later that year, Arnold was cast as Sharla Valentine, a high-school friend of Emily Ann Sago (played by Liz Vassey) on the ABC-TV daytime drama All My Children. She continued in the role until 1991.
Arnold's best-known television role was Pamela James on Martin Lawrence's sitcom Martin (1992–1997). She also played the recurring role of Nicole Barnes on the sitcom One on One. In 2000, she was reunited with Martin Lawrence in Big Momma's House. In 2007, she again reunited with Lawrence (this time as his character's wife) in the big screen road comedy/buddy film Wild Hogs. In 2003, she appeared in Civil Brand. Arnold played the role of the matriarch, Rochelle, on the sitcom Everybody Hates Chris which premiered in September 2005 and ended in May 2009. In a departure from her known comedic roles, she played the title role in The Lena Baker Story (2008), which was about the first and only woman to be executed by the electric chair in Georgia.
Arnold also played the voice of the friend in The Boondocks episode "Attack of the Killer Kung-Fu Wolf Bitch", which aired in 2007. In 2009, Arnold appeared onstage in The Wiz revival at the New York City Center in the part of Evillene, The Wicked Witch of the West. In 2010 she guest starred in the one-hour episode premiere of the Disney XD Original Series Pair of Kings as Aunt Nancy, and also reprise her role for one more episode.
Arnold played the best friend of Fran Drescher in the TV Land sitcom Happily Divorced, which is based on Fran Drescher's real-life marriage and divorce to series co-creator Peter Marc Jacobson.
She made her biggest break ever in The Neighborhood, the success of which that in March 2026 that she signed a first look deal with CBS Studios.