Overview
Tomorrow and Tomorrow is a 1997 science fiction novel by Charles Sheffield. The book starts in approximately the year 2020 and follows the protracted adventures of Drake Merlin, in his quest to save his wife from a terminal brain disease, over the course of eons. Similar premises are presented in the 2006 film The Fountain, as well as the Isaac Asimov story "The Last Question".
Plot summary
Originally, Drake is a professional musician, with minor celebrity. When his wife Ana is diagnosed with an unspecified incurable brain disorder, Drake exhausts every option attempting to cure her. Only then does he decide to have her body cryogenically stored, in the hopes future generations will discover an effective treatment. However, Drake is extremely cautious, and in case the future culture doesn't care about her plight, he has himself frozen as well. Furthermore, he devotes all his energies for a decade before his freezing to becoming an expert primary source on the musically notable people of his era. He correctly assumes that if you become the world's foremost expert in any subject, eventually someone will want to write a book on that exact subject. At that time the hypothetical future writer will want to awaken Drake, and he can in turn awaken his wife, if treatment is available. He is awakened in the year 2512. Although society is vastly different, no cure for Ana yet exists. He spends six years apprenticed to a musical historian to pay for his reviving costs and to gain a foothold in this new world.
Drake is continually laid dormant and revived, progressively later into the future, all the way until the time of the Big Crunch. Human civilization alters radically over the eons, but Ana's mangled brain proves an extremely difficult problem. Despite the incomprehensible changes surrounding him in each successive awakening, Drake never loses sight of his mission.
Eventually, in the extremely remote posthuman future a few billion years later, Drake's original biological body has disintegrated, despite the cryogenic treatment, and he has become an uploaded consciousness, though still in stasis. At this point the descendants of humanity have colonized the entire Milky Way galaxy, yet an inexplicable threat is wiping out their colonies in a widening arc. The leaders of this civilization have exhausted every answer they can conceive of and have no information as to even the cause of the threat.
From Wikipedia (CC BY-SA 4.0).