Acting and television hosting
Following her appearance in an episode of Apple's Way, Bertinelli was approached by producer Norman Lear to audition for the role of cooperative daughter Barbara Cooper in the sitcom One Day at a Time, which debuted in late 1975 when Bertinelli was 15. She appeared in 208 of the 209 episodes before it left the air on May 28, 1984, and she won two Golden Globe Awards for her performances. In the 2005 One Day at a Time Reunion Special, she was reunited with cast members Bonnie Franklin, Mackenzie Phillips and Pat Harrington Jr. to watch memorable clips from the show's nine seasons. They talked about actors who had appeared on the show as well as Phillips's drug problem, which had wreaked havoc on-set and caused Phillips to be fired.
After One Day at a Time, Bertinelli starred in several TV films and miniseries and made many guest appearances on other television shows. In the 1990s, she starred in two short-lived sitcoms: Sydney, as the title character, a private detective (with Matthew Perry and Craig Bierko); and Café Americain. In 2001, she joined the cast of Touched by an Angel for its last two seasons.
From 2010 to 2015, she starred in the sitcom Hot in Cleveland with Betty White, Wendie Malick and Jane Leeves. Its six-season run concluded June 3, 2015.
In 2015, Bertinelli began hosting cooking TV shows Valerie's Home Cooking and Kids Baking Championship with cake artist Duff Goldman on the Food Network. She won two Daytime Emmy Awards for her work on Valerie's Home Cooking. In 2019, she hosted two Food Network shows, Family Food Showdown and Family Restaurant Rivals.
In June 2021, it was announced that Bertinelli would star opposite Demi Lovato in NBC's single-camera comedy television pilot, Hungry. In December 2021, she signed a new deal with Food Network. In January 2024, she confirmed that she had been cut from Kids Baking Championship by Food Network.