Villena is a Spanish surname. Notable people with the surname include:
Ahron Villena (born 1987), Filipino actor
Andrés Villena (born 1993), Spanish professional volleyball player
Arturo Moyers Villena (1930–2013), Mexican muralist and painter
Daniela Santiago Villena (born 1982), Spanish transgender model and actress
Diego Valverde Villena (born 1967), Spanish poet, essayist, and polyglot
Enrique de Villena, Spanish medieval writer and scientist
Guillermo Lohmann Villena (1915–2005), Peruvian diplomat, historian, lawyer, and writer
Isabel de Villena (c.1430–1490), the illegitimate child of Enrique de Villena
Ingrid Villena (born 1990), Chilean lawyer
Jaime Villena (1897–1975), Spanish footballer
Javier Villena (born 1966), Spanish retired footballer
Jose Nicolás Baltasar Fernández de Piérola y Villena (1839–1913), Peruvian politician
Josh Villena, guitarist of the Spanish band Autotelic
Luis Antonio de Villena, contemporary Spanish poet and writer
Luis Flores Villena (born 1964), Peruvian football manager
Mel Villena, Filipino musician, composer, and musical director
Pedro Pacheco de Villena (1488–1560), Spanish cardinal
Rubén Martínez Villena (1899–1934), Cuban writer, lawyer, and revolutionary leader
Rodolfo Villena Hernández (born 1968), Mexican artisan