William Murdoch (1754–1839) was a Scottish engineer and inventor.
William Murdoch may also refer to:
William Murdoch (bishop) (born 1949), American Anglican bishop
William Murdoch (pianist) (1888–1942), Australian concert pianist
William Murdoch (poet) (1823–1887), Canadian poet
William Murdoch (politician) (1904–1984), Speaker of the Ontario Legislature, 1960–1963
William Gordon Burn Murdoch (1862–1939), Scottish painter, travel writer and explorer
William McMaster Murdoch (1873–1912), RMS Titanic's First Officer
William W. Murdoch (born 1939), professor of population ecology at the University of California, Santa Barbara
W.C.W. Murdoch (1914–1987), Scottish rugby player
Billy Murdoch (1854–1911), Australian cricket's greatest batsman of the 19th century
Billy Murdoch (footballer) (born 1949), Scottish footballer for Stenhousemuir and Kilmarnock
In fiction
Detective William Murdoch, the investigator in Murdoch Mysteries