William Francis O'Shea, M.M. (December 9, 1884 – February 22, 1945) was an American Roman Catholic bishop who served as the Vicar Apostolic of Heijo in Korea from 1939 to 1944.
Born in Greenwich Valley of New York City, New York, United States on December 9, 1884, he was ordained a priest for the Catholic Foreign Mission Society of America on December 5, 1917. O'Shea was appointed the Vicar Apostolic of Heijo and Titular Bishop of Naissus on July 11, 1939. He was consecrated by Pope Pius XII on October 29, 1939, with archbishops Celso Benigno Luigi Costantini and Henri Streicher serving as co-consecrators.
O'Shea resigned on April 17, 1944 and died on February 22, 1945, aged 60.