2018–present: established actress
Deutch starred opposite her Everybody Wants Some costar Glen Powell, in Netflix's 2018 romantic comedy Set It Up. The story follows two overworked assistants who try to get their horrible bosses out of their hair by setting them up together. She also landed a role in the drama-comedy The Professor alongside Johnny Depp. In May 2019, the makers of Set It Up announced that Deutch will be reuniting with Glen Powell for another rom-com tentatively titled Most Dangerous Game. In July 2018, it was announced that Deutch would be starring in Ryan Murphy's new web television comedy series on Netflix, The Politician alongside Ben Platt and Gwyneth Paltrow, which was released on Netflix on September 27, 2019.
In Tanya Wexler's crime comedy drama Buffaloed (2019), Deutch played the lead role of Peg Dahl, a con artist who, while on parole for her crimes and in a desperate attempt to escape her hometown of Buffalo, New York, becomes a debt collector. Co-produced by Deutch herself, and co-starring Judy Greer, Jermaine Fowler, Noah Reid and Jai Courtney, the film premiered at the Tribeca Film Festival to positive reviews from critics. Upon its limited theatrical release in February 2020, the film received further praise. In her review for The Los Angeles Times, Kimber Myers applauded Deutch's performance, saying she "immediately takes the audience hostage in the opening moments of Buffaloed [...] the actress owns this sharp comedy — and everyone watching — playing the type of character we still don’t see that often on screen." Sheila O'Malley of RogerEbert.com called the film, "a showcase for the mega-talented Deutch", saying Deutch "tosses herself into the role like a maniacal fidget-spinner, all flash and charm." Concluding her review of the film, O'Malley wrote, "Buffaloed is refreshing in how it challenges these norms, and in so doing, gives Deutch—who has already proven her comedic acting chops in Everybody Wants Some!!, Zombieland: Double Tap and the Netflix series The Politician—a chance to shine at the center of the narrative." TheWrap's Elizabeth Weitzman was more critical of the film, calling it "uneven", while The New York Times' Jeannette Catsoulis penned "Simultaneously rowdy and slick, Buffaloed is exuberantly paced and entirely dependent on Deutch’s moxie and pell-mell performance."
Deutch starred as Madison in Zombieland: Double Tap, which was released October 11, 2019. She received positive reviews for her performance, and was nominated at the 2020 Fangoria Chainsaw Awards for Best Supporting Actress. In 2020, Deutch starred in the Quibi television series adaptation Home Movie: The Princess Bride, to raise money for World Central Kitchen. In 2021, she appeared in the music video "Anyone", a song by Canadian singer Justin Bieber. She also joined Hound as the lead character "Callie" as well as producer. She voiced a role in an adult animated comedy series Fairfax which premiered on Amazon Prime Video in October 2021. Deutch starred in Graham Moore's directorial debut The Outfit (2022) alongside Mark Rylance and Dylan O'Brien which premiered at the 72nd Berlin International Film Festival. The same year she starred in Quinn Shephard's satire film Not Okay, which was released on Hulu. She starred and executive produced Something From Tiffany's, an Amazon Original film co-produced by Reese Witherspoon and Hello Sunshine, based on the Melissa Hill novel.
In 2024, Deutch starred opposite Nicholas Hoult and Toni Collette in the drama thriller Juror #2, from director Clint Eastwood in his purported final effort as a filmmaker. The film received positive reviews from critics, as did her performance. From October 2024 to January 2025, she played Emily Webb, in a Broadway revival of the Thorton Wilder play Our Town at the Ethel Barrymore Theater. She acted alongside Jim Parsons and Katie Holmes in a production directed by Kenny Leon. Shania Russell of Entertainment Weekly wrote, "Deutch making her Broadway debut, is as instantly likable as ever. She balances easy charisma with distinct vulnerability". For the biographical film Nouvelle Vague, she reunited with director Richard Linklater portraying Jean Seberg during the period leading up to the latter's breakthrough role in the French New Wave film Breathless (1960). The film had its premiere at the 2025 Cannes Film Festival, where it was met with positive reviews from critics and audience alike. Critics describe her as being "well-cast" and "convincing" in the role. Pete Hammond of Deadline Hollywood described her as being "terrific", adding, "Deutch is especially impressive as Seberg. There wasn’t a moment I thought I was watching anyone else but Seberg." For the role, she earned a nomination for the Independent Spirit Award for Best Supporting Performance and several publications, including Variety, believed her worthy of a nomination for Best Supporting Actress at the 98th Academy Awards, though no nomination eventuated. Time included the performance in its selection of the best of 2025 in film. Deutch's third and final film of 2025 was the dystopian thriller film Anniversary, in which she starred opposite Diane Lane, Kyle Chandler, Madeline Brewer, Phoebe Dynevor, Mckenna Grace, Sky Yang, and Dylan O'Brien.
In 2026, Deutch starred in Gail Daughtry and the Celebrity Sex Pass, a David Wain-directed comedy parodying Hollywood culture, with critics noting her energetic comedic performance as the emotional anchor of the film's absurdist tone. She also led the Netflix romantic comedy Voicemails for Isabelle, opposite Nick Robinson, where her performance was widely praised for its emotional depth and vulnerability, with reviewers highlighting how she balanced humor and grief in a role that became central to the film's major streaming success.
